“Korean skin boosters are more than hydration — they’re ‘liquid gold’ that rebuilds skin at the cellular level.”
Korea is the world’s most advanced country in skin boosters and injectable skin treatments. Korean clinics offer a far wider range of skin booster types than anywhere else — from the classic Rejuran series to cutting-edge Exosome skin boosters and RE2O oxygen skin boosters, each with unique benefits and ideal candidates.
This guide gives you a comprehensive breakdown of Korea’s most popular skin booster types, helping you find the skin care solution that’s right for you.
1. Rejuran Series — Korea’s Iconic Skin Booster
Rejuran is Korea’s most iconic skin booster brand. Its core ingredient is polynucleotide (PN/PDRN) extracted from salmon, which repairs damaged skin cells at the DNA level and stimulates collagen regeneration. Almost every dermatology clinic in Korea offers Rejuran — it truly is the nation’s go-to skin booster.
Rejuran Healer (Red Box) — Classic Repair
The classic Rejuran formulation and the most widely used skin booster in Korea. Moderate PN concentration focused on skin repair and regeneration. Benefits: Repairs damaged skin barrier, improves skin texture, thickens the dermis, boosts skin elasticity, minimises pores. Ideal for: All skin types, especially thin skin, compromised barrier, and sensitive skin. Recommended course: 3–4 sessions, 2–4 weeks apart. Reference price: ₩150,000–300,000 per session.
Rejuran HB (Black Box) — Deep Hydration
PN combined with hyaluronic acid (HA) for dual repair and deep moisturisation. Smoother texture makes injection more comfortable. Benefits: All the repair power of the red box, plus deep moisture-locking, instant radiance, and relief of dryness and roughness. Ideal for: Dry skin, seasonal sensitivity and flaking, and anyone wanting an immediate glow. Reference price: ₩200,000–350,000 per session.
Rejuran i (White Box) — Eye Area Specialist
Specifically developed for the delicate eye area. Smaller PN molecule weight and finer concentration, suited to the thin skin around the eyes. Benefits: Fades dark circles, reduces fine lines around the eyes, thickens periorbital skin, brightens under-eye shadows. Ideal for: Severe dark circles, pronounced eye area wrinkles, and post-blepharoplasty recovery. Can be combined with the red or black box for a full-face plus eye area treatment. Reference price: ₩150,000–250,000 per session.
Rejuran S (Blue Box) — Scar Repair
High-concentration PN formulation specifically targeting acne scars and atrophic scarring. Benefits: Promotes scar tissue remodelling, improves the uneven texture of acne pits, and strengthens the skin’s natural regenerative ability. Ideal for: Acne scars and pits, surgical scars, atrophic scars, and enlarged pores. Best results when combined with laser treatment. Reference price: ₩200,000–350,000 per session.
How to Choose the Right Rejuran
- Daily maintenance / first-time treatment → Healer (Red Box)
- Dry skin / want an instant glow → HB (Black Box)
- Eye area concerns → i (White Box)
- Acne scar repair → S (Blue Box)
- Best combination → Red/Black Box full face + White Box eye area + Blue Box targeted scar spots
2. Exosome Skin Booster — The New Frontier of Regenerative Medicine
Exosome therapy is the hottest ingredient in Korean dermatology right now. Exosomes are nano-scale vesicles secreted by cells, carrying a wealth of growth factors, mRNA, and proteins that deliver “repair instructions” directly to skin cells — more precise and more effective than traditional growth factors.
Core benefits: Activates the skin’s self-repair at the cellular signalling level; powerful anti-inflammatory and barrier restoration; promotes new collagen and elastin formation; improves pigmentation and evens skin tone; accelerates post-procedure recovery (highly effective after laser, thread lift, or surgery).
Popular Korean Exosome brands: ASCE+, ExoSCRT, Cellthera. Korean clinics typically combine Exosome with skin boosters, MTS microneedling, or laser to deliver exosomes directly into the dermis. Ideal for: Dull and ageing skin, post-procedure recovery, sensitive skin repair, and those seeking the most advanced anti-ageing results. Reference price: ₩300,000–800,000 per session.
3. RE2O — Human Dermal ECM Skin Booster
RE2O is a revolutionary ECM skin booster launched in Korea in 2024. It is the world’s first injectable skin product to extract extracellular matrix (ECM) from human dermal tissue — injecting real human collagen and elastin directly into your skin.
Core ingredients: Acellular allograft dermis (hADM) microparticles containing 89% collagen + 3% elastin + 7.6% other ECM components + 0.4% hyaluronic acid (GAG). Once injected, it directly replenishes the structural components lost from the dermis while simultaneously inducing the body’s own collagen regeneration.
How RE2O differs from traditional skin boosters: Conventional skin boosters (such as Rejuran) “stimulate” the skin to produce its own collagen; RE2O “directly replenishes” genuine human dermal components into the skin, delivering more direct and longer-lasting results.
Benefits: Noticeably firmer skin, reduced pore size, improved fine lines, and an overall enhancement in skin quality. Effects gradually appear 1–2 weeks after treatment and reach their peak at 2–3 months. Treatment plan: An initial intensive course of 3 sessions spaced 2–3 months apart is recommended; subsequent maintenance effects can last 12–18 months. Reference price: ₩500,000–700,000 per session.
4. Laetigen — 99.9% Pure Collagen Skin Booster
Laetigen is a high-purity collagen injectable certified by Korea’s Ministry of Food and Drug Safety (MFDS). Its core ingredient is 99.9% pure Type I collagen — the primary structural protein that makes up over 70% of human skin. Laetigen injects pure collagen with exactly the same structure as the skin’s own collagen directly into the dermis, instantly replenishing lost collagen.
Core ingredients: Type I collagen (99.9% purity) + glycine (stabilises the collagen triple helix). Highly compatible with the body, with an extremely low risk of rejection.
Benefits: Immediate improvement in skin elasticity and firmness, reduction in fine lines and wrinkles, minimised pores, and enhanced skin texture and luminosity. Skin feels noticeably firmer and more plump right after treatment; collagen regeneration effects become visible 2–4 weeks later. Treatment plan: Initially recommended once every 4 weeks for 3 sessions. A single session lasts 4–6 months; 3 or more sessions can maintain results for over 12 months. Reference price: ₩300,000–500,000 per session.
Laetigen vs RE2O: Laetigen focuses on pure collagen direct replenishment; RE2O provides the complete ECM dermal matrix (collagen + elastin + other components). Both are “direct replenishment” types, but differ in composition and emphasis. They can be selected individually or combined according to skin needs.
5. Other Popular Korean Skin Boosters
NCTF / Filorga Skin Booster
A French brand containing 55 active ingredients (vitamins, amino acids, minerals, coenzymes). Widely used in Korean clinics. Focuses on comprehensive nutritional replenishment and antioxidant protection. Reference price: ₩200,000–400,000 per session.
Juvelook / Collagen Skin Booster
Contains PDLLA (poly-D,L-lactic acid), which continuously stimulates collagen production for 3–6 months after injection. Korea’s latest-generation “collagen booster.” Ideal for collagen loss and skin laxity. Reference price: ₩250,000–500,000 per session.
Profhilo
Ultra-high concentration hyaluronic acid (64mg/2ml), administered via a 5-point injection technique. Focuses on bio-remodelling and overall firming and lifting. Reference price: ₩300,000–600,000 per session.
Who Is This For?
- Dry, dull skin lacking radiance — wanting to improve skin quality from the inside out
- Enlarged pores and rough texture — pursuing smooth, baby-soft skin
- Acne scars, pits, and pigmentation — needing repair treatment
- Eye area fine lines and dark circles — prominent periorbital skin concerns
- Anti-ageing maintenance from age 25 — prevention is better than cure
- Post-laser, thread lift, or surgical recovery — wanting to accelerate healing
- Needle-averse but wanting skin improvement — (needle-free RE2O option available)
BeautsGo Popular Skin Booster Combinations
- TOP 1 Korean Glass Skin Package: Rejuran Healer + Exosome + RE2O — repair + regeneration + dermal replenishment all in one
- TOP 2 Eye Area SOS: Rejuran i (eye area) + Exosome — say goodbye to panda eyes
- TOP 3 Acne Scar Conquest: Rejuran S + Fractional Laser — dual repair and remodelling treatment
- TOP 4 Collagen Direct Boost: Laetigen + RE2O — pure collagen + ECM dual dermal replenishment
BeautsGo Service Process
- Free online consultation — tell us your skin concerns and goals
- Treatment recommendation — match the best skin booster type to your skin
- In-person visit to Korea — VIP transfer and interpreter accompaniment to the clinic
- Skin analysis — professional skin assessment with Korean clinic equipment
- Customised treatment — available as a single session or a full course
- Post-treatment care guidance — aftercare instructions and follow-up skincare advice
- Ongoing follow-up — results tracking and treatment planning
FAQ
Q: How often should I get skin booster treatments? The Rejuran series is recommended every 2–4 weeks, with 3–4 sessions per course; Exosome every 2–4 weeks; RE2O can be done every 1–2 weeks. Frequency can be reduced during the maintenance phase.
Q: Is it painful? How long is the recovery? Korean clinics apply topical anaesthetic for 20–30 minutes before the injection, so you’ll feel only mild discomfort. Small bumps may appear after Rejuran injections (subsiding within 1–3 days); Exosome and RE2O have virtually no downtime.
Q: What’s the difference between Rejuran and ordinary skin boosters? Ordinary skin boosters primarily contain hyaluronic acid (for hydration). Rejuran’s PN/PDRN ingredient repairs DNA and stimulates collagen regeneration, delivering deeper and longer-lasting results.
Q: Can multiple skin boosters be done at the same time? Yes. Korean clinics often administer different ingredients in layers during a single session (e.g., Rejuran + Exosome), or use different products on different areas.
*Prices are 2026 reference rates for the Gangnam district of Seoul, including BeautsGo interpreter accompaniment service.
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