Neck wrinkles — sometimes called “necklace lines” — are among the most stubborn signs of aging. They appear earlier than many people expect and resist most topical treatments. If you’re considering a professional filler treatment in Korea, two leading options stand out: hyaluronic acid (HA) filler and RE2O (리투오), a PDRN-based collagen regenerative filler. This guide breaks down how each works, what results to expect, and how much they cost so you can make an informed choice.
Understanding the Two Approaches
Hyaluronic Acid (HA) Filler
Type: Physical volumizing filler
HA fillers are cross-linked gel injections that physically fill in wrinkle grooves. The gel sits beneath the skin, instantly plumping the crease from below. HA is a substance naturally found in the body, making it highly biocompatible. Results are visible immediately after injection.
RE2O (리투오) Collagen Filler
Type: PDRN collagen regenerative filler
RE2O is a high-concentration PDRN formulation designed specifically for filling-type treatment. It is injected as a collagen filling procedure along wrinkle lines, stimulating the body’s own collagen production to rebuild dermal structure from within. Unlike skin boosters or water-light injections, RE2O is a true filler product that targets wrinkle lines directly.
Injection Techniques
HA Filler Injection Methods
- Linear threading: A cannula or needle is advanced along the length of the wrinkle, depositing filler in a continuous line beneath the crease.
- Serial puncture: Multiple small deposits are placed at regular intervals along the wrinkle line for even distribution.
- Fanning technique: From a single entry point, filler is deposited in a fan-shaped pattern to cover wider areas along the wrinkle lines.
RE2O (리투오) Injection Method
RE2O uses a collagen filling injection along wrinkle lines, delivering the high-concentration PDRN formulation directly into the mid-deep dermis where collagen regeneration is most effective. This targeted filling approach follows the natural wrinkle pattern, ensuring precise delivery for optimal collagen stimulation and structural rebuilding. RE2O is not administered via mesotherapy or multi-point injection — it is a focused filling treatment along each wrinkle line.
Head-to-Head Comparison: HA Filler vs RE2O
| Category | HA Filler | RE2O (리투오) |
|---|---|---|
| Mechanism | Physical gel fills wrinkle grooves, providing instant volume | PDRN collagen regenerative filler stimulates natural collagen production along wrinkle lines |
| Onset of Results | Immediate — visible right after injection | Gradual — noticeable improvement over 2–4 weeks as collagen rebuilds |
| Best Wrinkle Types | Deep, well-defined horizontal neck lines | Early to moderate wrinkles; fine lines and crepey skin texture |
| Injection Method | Linear threading, serial puncture, fanning along wrinkle lines | Collagen filling injection along wrinkle lines into mid-deep dermis |
| Sessions Required | 1 session | 2–3 sessions (spaced 3–4 weeks apart) |
| Duration of Results | 6–12 months | 12–18 months |
| Pain Level | Moderate (topical numbing applied) | Moderate (topical numbing applied) |
| Downtime | 1–3 days (mild swelling, possible bruising) | 1–2 days (minimal swelling) |
| Risks / Side Effects | Swelling, bruising, rare lumps or Tyndall effect if injected too superficially | Mild redness, slight swelling; very low risk profile |
| Single Session Cost | 400,000–700,000 KRW per cc | 300,000–500,000 KRW per session |
| Estimated Annual Cost | 800,000–1,400,000 KRW | 900,000–1,500,000 KRW |
| Reversibility | Yes — can be dissolved with hyaluronidase injection | No enzyme reversal, but RE2O has an excellent safety profile and is naturally absorbed |
Which One Should You Choose?
Choose HA Filler If:
- You have deep, pronounced neck wrinkles that need immediate physical filling
- You want instant visible results — especially if you have an upcoming event
- You prefer a treatment that can be reversed if needed
- You are visiting Korea for a short stay and need a single-session solution
Choose RE2O (리투오) If:
- Your neck wrinkles are early-stage or shallow and you want to prevent them from deepening
- You want to improve overall skin quality — firmness, elasticity, and texture — in addition to reducing wrinkles
- You prefer a longer-lasting result (12–18 months) through natural collagen regeneration
- You can schedule 2–3 visits to Korea or plan a longer stay for the full treatment course
Combined Protocol: Getting the Best of Both
Many Korean clinics recommend a combined approach for optimal results. Here is a typical timeline:
| Timeline | Treatment | Purpose |
|---|---|---|
| Week 1 | HA filler injection | Immediately fill deep wrinkle grooves for instant improvement |
| Week 3–4 | RE2O session #1 | Begin collagen regeneration to rebuild dermal structure |
| Week 7–8 | RE2O session #2 | Continue collagen stimulation for long-term firmness |
| Month 6 | Maintenance evaluation | Assess results and plan touch-up if needed |
This combined protocol delivers immediate wrinkle reduction from HA while building a foundation of new collagen through RE2O for sustained improvement.
Tips for International Visitors Coming to Korea
- Visa: Apply for a C-3-3 medical tourism visa for your treatment visit. BeautsGo can assist with the visa application process.
- Allergy history: If you are considering RE2O, inform your doctor about any allergies to PDRN or salmon-derived ingredients. A patch test may be recommended.
- Timing: Avoid scheduling treatment during menstruation or pregnancy, as sensitivity and bruising risk may increase.
- Aftercare: Avoid excessive neck movement, sun exposure, saunas, and intense exercise for 48–72 hours after injection. Sleep on your back if possible for the first few nights.
- BeautsGo services: BeautsGo provides comprehensive support including C-3-3 visa service, professional translation and interpreter services, car transportation, and accommodation arrangements to make your medical trip seamless.
Frequently Asked Questions
1. How long do HA filler results last on the neck?
HA filler results on the neck typically last 6–12 months. The neck area moves frequently, so filler may metabolize slightly faster than in less mobile areas. Touch-ups every 8–12 months help maintain results.
2. Is RE2O (리투오) the same as Rejuran?
No. While both contain PDRN, RE2O and Rejuran are completely different products. RE2O is a high-concentration formulation designed specifically for filling-type treatment, using collagen filling injection along wrinkle lines. Rejuran is typically used as a skin rejuvenation treatment. RE2O targets wrinkle lines directly as a filler product.
3. Can I get both treatments on the same day?
It is generally recommended to space treatments at least 2–3 weeks apart. Performing both on the same day increases swelling risk and makes it harder to evaluate individual results. The combined protocol timeline above is the standard recommendation.
4. How painful is neck filler injection?
Both HA and RE2O treatments involve moderate discomfort. Topical numbing cream is applied 20–30 minutes before the procedure. Most patients describe the sensation as mild pressure or pinching. The neck is slightly more sensitive than the face, but the procedure is very tolerable.
5. What should I avoid after neck filler treatment?
For 48–72 hours after treatment, avoid: intense exercise, saunas and steam rooms, direct sun exposure, excessive neck bending or stretching, and alcohol consumption. Sleeping on your back is recommended for the first 2–3 nights.
6. Are there any serious risks?
Both treatments have excellent safety profiles when performed by experienced practitioners. HA filler carries a small risk of lumps, Tyndall effect (bluish discoloration), or vascular occlusion if improperly injected. RE2O has a very low risk profile — mild redness and swelling are the most common side effects. Always choose a board-certified dermatologist or plastic surgeon.
7. How much should I budget for a neck filler trip to Korea?
For the treatment alone: a single HA session runs 400,000–700,000 KRW per cc, while RE2O costs 300,000–500,000 KRW per session. If pursuing the combined protocol (1 HA + 2–3 RE2O sessions), budget approximately 1,300,000–2,200,000 KRW for treatments. BeautsGo can help with travel logistics including visa, transportation, accommodation, and interpretation to keep your overall trip costs manageable.
Ready to Start? Contact BeautsGo
BeautsGo connects you with trusted Korean clinics for professional neck wrinkle filler treatments. We provide full-service support: C-3-3 visa assistance, professional translation and interpreter services, car transportation, and accommodation. Reach us through any of the channels below:
LINE
Mini Program
